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400 publications mentioning the Prestwick Chemical Library®

Torres, N. S. et al.
Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a Commercially Available Small Compound Library With Colistin Against Pseudomonas aeruginosa. Frontiers in Microbiology |9, 1–12 (2018).

Zeinab Mamouei, Abdullah Alqarihi, Shakti Singh, Shuying Xu, Michael Mansour, Ashraf S Ibrahim, Priya Uppuluri.
Alexidine dihydrochloride has broad spectrum activities against diverse fungal pathogens. (2018)

Luke John Alderwick, Panchali Kanvatirth, Gurdyl Besra, Rose E Jeeves, Joanna Bacon.
Utilisation of the Prestwick Chemical Library ® to identify drugs that inhibit the growth of Mycobacteria 1–40 (2018).

Chakraborty, M., Sellier, C., Ney, M., Pascal, V. & Charlet-berguerand, N.
Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy. 1, 1–12 (2018).

Aviolat, H., Nominé, Y., Gioria, S. & Bonhoure, A. SynAggreg.
A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds. 1–23 (2018).

Gina Wall, Ashok K. Chaturvedi, Floyd L. Wormley, Jr., Nathan P. Wiederhold, Hoja P. Patterson, Thomas F. Patterson, J. L. L.-R.
Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development. Antimicrob. Agents Chemother (2018).

Fernandez, M. et al.
Toxic Colors : The Use of Deep Learning for Predicting Toxicity of Compounds Merely from Their Graphic Images Introduction The discovery of new chemicals and materials plays a key role in technological innovation and. (2018).

Palandri, A., Martin, E., Russi, M. & Rera, M.
Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich’ s ataxia. Disease Models & Mechanisms (2018).

Tauziede-Espariat, A. et al.
High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors Report High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors. 1737–1745 (2017).

Tione Buranda, Catherine Gineste, Yang Wu, Virginie Bondu, Dominique Perez, Kaylin R. Lake, Bruce S. Edwards, Larry A. Sklar A
High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry. Slas Discovery Vol 23, Issue 7, 2018 (2018).

Melissa Conte, Josselin Lupette, Khawla Seddiki, Coline Meï, Lina-Juana Dolch, Valérie Gros, Caroline Barette, Fabrice Rébeillé, Juliette Jouhet, Eric Maréchal
Screening for biologically annotated drugs that trigger triacylglycerol accumulation in the diatomPhaeodactylum. Plant Physiology (2018).

Coutard, B. et al.
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay. Antiviral Research 144, 330–339 (2017).

Jung, H. et al.
Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice. Diabetes Obes Metab. 1–14 (2018).

Sandra M. W. van de Wiel, D. Rudi de Waart, Ronald P. J. Oude Elferink, and Stan F. J. van de Graaf.
Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter a-b. Cell Mol Gastroenterol Hepatol 5:223–237 (2018).

Astol, A. et al.
Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors. J.MedChem 60, 1598−1604 (2017).

Eren, R. O. et al.
Development of a semi-automated image-based high-throughput drug screening system. Front Biosci 242–253 (2018).

Jones, C. L., Njomen, E., Dexheimer, T. S. & Tepe, J. J.
Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins. ACS Chem. Biol. 12, 2240−2247 (2017).

O. L. M. Meijer, P. van den Biggelaar, R. Ofman , F. A. Wijburg, N. van Vlies.
High-Throughput Screen Fails to Identify Compounds That Enhance Residual Enzyme Activity of Mutant N- Acetyl- a -Glucosaminidase in Mucopolysaccharidosis Type. JIMD Reports (2017).

Reis, S. Dos et al.
Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs. 3,5 e2174 PLoS ONE (2008).

Gug, F., Oumata, N. & Blondel, M.
Synthesis of Conjugates of 6-Aminophenanthridine and Guanabenz , Two Structurally Unrelated Prion Inhibitors , for the Determination of Their Cellular Targets by Affinity Chromatography. Bioconjugate Chem 279–288 (2010).

Dos, S. et al.
Biochimie Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding. Biochimie 93, 1047–1054 (2011).

Nguyen, P. et al.
Structure − Activity Relationship Study around Guanabenz Identifies Two Derivatives Retaining Antiprion Activity but Having Lost α 2- Adrenergic Receptor Agonistic Activity. ACS Chem. Neurosci. 2014, 5, 1075−1082 (2014).

Dunman, Paul M., Krysan, Damian J., Flaherty, D. P.
Methods and composition for treating infections. ( 2017). Patent US 2017/0065540A1

Dong, J. et al.
Biochimica et Biophysica Acta Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells . Implication of inositol 1 , 4 , 5-triphosphate receptor dependent. 1864, 1018–1027 (2017).

Smith, C. N. J. et al.
Identifying ligands at orphan GPCRs : current status using structure-based approaches Tables of Links. British Journal of Pharmacology 173, 2934-2951 (2016).

Jones, L. H. & Bunnage, M. E.
Applications of chemogenomic library screening in drug discovery. Nat. Publ. Gr. 16, 285–296 (2017).

Jihu Dong, J., Aulestia, F.J., Kahn, S.A., Zeniou, M., Haiech, J., Kilhoffer, M.C.
Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, In Press

Varbanov, H.P., Kuttler, F., Banfi, D., Turcatti, G., Dyson, P.J.
Repositioning approved drugs for the treatment of problematic cancers using a screening approach. PLoS ONE, 2017, 12(2), e0171052

Tournu, H., Carroll, J., Latimer, B., Dragoi, A.M., Dykes, S., Cardelli, J., Peters, T.L., Eberle, K.E., Palmer, G.E.
Identification of small molecules that disrupt vacuolar function in the pathogen Candida albicans. PLoS ONE, 2017, 12(2), e0171145

Levoin, N., Labeeuw, O., Billot, X., Calmels, T., Danvy, D., Krief, S., Berrebi-Bertrand, I., Lecomte, J.M., Schwartz J.C., Caper, M.
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. European Journal of Medicinal Chemistry, 2017, 125, 5, 565–572

Neira, J.L., Bintz, J., Arruebo, M., Rizzuti, B., Bonacci, T., Vega, S., Lanas, A., Velázquez-Campoy, A., Iovanna, J.L., Abián, O.
Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma. Sci Rep, 2017, 7, 39732

Messer, J., Cham, C., Zhu, X., Patno, N.; Tao, Y., Chang, E.
PD-235 Targeting HMGB1-dependent Survival and Energy Production Pathways to Improve Mucosal Healing during IBD. Inflammatory Bowel Diseases, Official Journal of the Crohn’s & Colitis Foundation of America, 2017, S77, PD-235

Tsai, S.Y., Chen, S., Evans, T.
Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling. Curr. Protoc. Stem Cell Biol. 2017, 40:1F.16.1-1F.16.13

Villacé, P., Mella, R.M., Roura-Ferrer, M., Valcarcel, M., Salado, C., Castilla, A., Kortazar, D.
Fluorescent Parkin Cell-Based Assay Development for the Screening of Drugs against Parkinson Disease.SLAS Discovery, Advancing Life Sciences R&D, 2017, 22, 1, 67–76

Kel, A.E., Stegmaier, P., Koschmann, J., Poroikov, V., Kel-Margoulis, O.V., Wingender, E.
Multi-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer. EuPA Open Proteomics, 2016, 13, 1–13
López-García, I., Gerő, D., Szczesny, B., Szoleczky, P., Olah, G., Módis, K., Zhang, K., Gao, J., Wu, P., Sowers, L. C., DeWitt, D., Prough, D. S., Szabo, C.
Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant. British Journal of Pharmacology, 2016

Seol, H.S., Lee, S.E., Song, J.E., Lee H.Y., Park, S., Kim, I., Singh, S.R., Chang, S., Jang, S.J.
Glutamate release inhibitor, Riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production. Cancer Letters, 2016, 382, 2, 157–165

Nylén, F., Bergman, P., Gudmundsson, G.H., Agerberth, B.
Assays for Identifying Inducers of the Antimicrobial Peptide LL-37 Antimicrobial Peptides, Protocol, 2016, volume 1548 of the series Methods in Molecular Biology, 271–281

Druzhyna, N., Szczesny, B., Plah, G., Modis, K., Asimakopoulou, A., Pavlidou, A., Papapetropoulos, A., Hellmich, M., Szabo, C.
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer. Pharmacological Research, 2016, 113, Part A, 18–37

Arvidsson, P. I., Sandberg, K., Forsberg-Nilsson, K.
Open for collaboration: an academic platform for drug discovery and development at SciLifeLab. Drug Discovery Today, 2016, 21(10):1690–1698

Bastin, J., Djouadi, F
Resveratrol and Myopathy. Nutrients, 2016, 8(5), 254

Cappato, S., Tonachini, L., Giacopelli, F., Tirone, M., Galietta, L. J. V., Sormani, M., Bocciardi, R.
High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva. Disease Models & Mechanisms , 2016, 9(6), 685–696

Chen, G., Masuda, A., Konishi, H., Ohkawara, B., Ito, M., Kinoshita, M., Ohno, K.
Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Scientific Reports, 2016, 6(April), 25317

Cheng, H., Chen, T., Tor, M., Park, D., Zhou, Q., Huang, J. B., Zhou, G.
A High-Throughput Screening Platform Targeting PDLIM5 for Pulmonary Hypertension. Journal of Biomolecular Screening, 2016, 21(4), 333–34

Chneiweiss, H., Junier, M.-P., Etienne, V.
Recycler un anti-hypertenseur pour combattre les tumeurs du cerveau. Communiqué de Presse National, (2016, April 15), Paris

Coleman, D. T., Gray, A. L., Stephens, C. A., Scott, M. L., Cardelli, J. A.
Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation. Oncotarget, 2016, 7(22), 1–10.

Druzhyna, N., Szczesny, B., Olah, G., Módis, K., Asimakopoulou, A., Pavlidou, A., Szabo, C.
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon. Pharmacological Research, 2016, 113, 18–37.

Ekins, S., Mietchen, D., Coffee, M., Stratton, T., Freundlich, J., Freitas-Junior, L., Andrade, C.
Open drug discovery for the Zika virus. F1000Research, 2016, 5(0), 150.

Fattahi, F., Steinbeck, J. A., Kriks, S., Tchieu, J., Zimmer, B., Kishinevsky, S., Studer, L.
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature, 2016, 531(7592), 105–9.

Gofshteyn, J., Cárdenas, A. M., Bearden, D.
Treatment of chronic enterovirus encephalitis with fluoxetine in a patient with X-linked agammaglobulinemia. Pediatric Neurology, 2016.

Guetschow, E. D., Kumar, S., Lombard, D. B., Kennedy, R. T.
Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. Analytical and Bioanalytical Chemistry, 2016, 408(3), 721–731.

Hasegawa, S., Kitoh, H., Ohkawara, B., Mishima, K., Matsushita, M., Masuda, A., Ohno, K.
Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. Biochemical and Biophysical Research Communications, 2016, 470(2), 356–361.

Holler, C. J., Taylor, G., McEachin, Z. T., Deng, Q., Watkins, W. J., Hudson, K., Kukar, T.
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Molecular Neurodegeneration, 2016, 11(1), 46.
Iglesias, A., Lage, S., Cadavid, M. I., Loza, M. I., Brea, J.
Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening. Journal of Biomolecular Screening, 2016.

Kang, J., Hsu, C.-H., Wu, Q., Liu, S., Coster, A. D., Posner, B. A., Wu, L. F.
Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Natural Biotechnology, 2016, 34(1), 70–77.

Koppel, J., Jimenez, H., Adrien, L., Greenwald, B. S., Marambaud, P., Cinamon, E., Davies, P.
Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer’s disease. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, 2016, 2(2), 121–130.

López, L. C., Varea, O., Navarro, S., Carrodeguas, J. A., Sanchez de Groot, N., Ventura, S., Sancho, J.
Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation. International Journal of Molecular Sciences, 2016, 17(6).

Nogueira, U., Dominguez, E., Loza, M. I., Blanco, F. J., Carames, B.
Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics. Osteoarthritis and Cartilage, 2016, 24, S18–S19.

Prado, S., Beltrán, M., Coiras, M., Bedoya, L. M., Alcamí, J., Gallego, J.
Bioavailable inhibitors of HIV-1 RNA biogenesis identified through a Rev-based screen. Biochemical Pharmacology, 2016, 107, 14–28.

Rhim, J. heon, Luo, X., Gao, D., Xu, X., Zhou, T., Li, F., Xia, X.
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells. Scientific Reports, 2016, 6(May), 26547.

Sakano, D., Choi, S., Kataoka, M., Shiraki, N., Uesugi, M., Kume, K., Kume, S.
Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass. Stem Cell Reports, 2016, 7(1), 95–109.

Samantaray, S., Correia, J. N., Garelnabi, M., Voelz, K., May, R. C., Hall, R. A.
Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages. International Journal of Antimicrobial Agents, 2016, 48(1), 69–77.

Shah, E. T., Upadhyaya, A., Philp, L. K., Tang, T., Skalamera, D., Gunter, J., Hollier, B. G.
Repositioning “old” drugs for new causes: identifying new inhibitors of prostate cancer cell migration and invasion. Clinical & Experimental Metastasis, 2016, 33(4), 385–399.

Timiri Shanmugam, P. S., Nair, R. P., De Benedetti, A., Caldito, G., Abreo, F., Sunavala-Dossabhoy, G.
Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells. Free Radical Biology and Medicine, 2016, 93, 217–226.

Torres, N. S., Abercrombie, J. J., Srinivasan, A., Lopez-Ribot, J. L., Ramasubramanian, A. K., Leung, K. P.
Screening a Commercial Library of Pharmacologically Active Small Molecules Against Staphylococcus aureus Biofilms. Antimicrobial Agents and Chemotherapy, 2016, July, AAC.00377-16.

Ulferts, R., de Boer, S. M., van der Linden, L., Bauer, L., Lyoo, H. R., Maté, M. J., van Kuppeveld, F. J. M.
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C. Antimicrobial Agents and Chemotherapy, 2016, 60(5), 2627–38.

Aggarwal, C., Jimenez, J. C., Lee, H., Chlipala, G. E., Ratia, K., Federle, M. J.
Identification of quorum-sensing inhibitors disrupting signaling between Rgg and short hydrophobic peptides in streptococci. mBio, 2016, 6(3), 1–11.

Ai, N., Wood, R. D., Welsh, W. J.
Identification of Nitazoxanide as a Group I Metabotropic Glutamate Receptor Negative Modulator for the Treatment of Neuropathic Pain: An In Silico Drug Repositioning Study. Pharmaceutical Research, 2015, 32(8), 2798–807.

Bergamo, A., Riedel, T., Dyson, P. J., Sava, G.
Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for mammary cancer. Investigational New Drugs, 2015, 33(1), 53–63.

Bharadwaj U., Eckols T., Kolosov M., Kasembeli T., Adam A., Torres D., Zhang X., Dobrolecki L., Wei Wei, Michael T. Lewis, Bhuvanesh Dave, Jenny C. Chang, Melissa D. Landis, Chad J. Creighton, M. A., Mancini, and D. J. T.

Ch’ng, J.-H., Moll, K., Quintana, M. del P., Chan, S., Moles, E., Liu, J., Wahlgren, M.
Cell-based Screening Identifies a Rosette-Disrupting Antimalarial for the Treatment of Plasmodium falciparum Malaria Complications. Blood, 2015, (February), 1–13.
Cheung, L., Yu, D. M. T., Neiron, Z., Failes, T. W., Arndt, G. M., Fletcher, J. I.
Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen. Biochemical Pharmacology, 2015, 93(3), 380–388.

Corbel, C., Zhang, B., Le Parc, A., Baratte, B., Colas, P., Couturier, C., Bach, S.
Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation. Chemistry and Biology, 2015, 22(4), 472–482.

Demishtein, A., Porat, Z., Elazar, Z., Shvets, E.
Applications of flow cytometry for measurement of autophagy. Methods, 2015, 75, 87–95.

Diener, S., Schorpp, K., Strom, T.-M., Hadian, K., Lorenz-Depiereux, B.
Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling. ASSAY and Drug Development Technologies, 2015, 13(8), 476–487.

Diener, S., Schorpp, K., Strom, T., Hadian, K., Lorenz-depiereux, B., Mu, H.,
Universita, T. Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling. ASSAY and Drug Development Technologies, 2015, (October), 476–487.

Divorty, N., Mackenzie, A. E., Nicklin, S. A., Milligan, G.
G protein-coupled receptor 35: An emerging target in inflammatory and cardiovascular disease. Frontiers in Pharmacology, 2015, 6(MAR), 1–13.

Grover, P., Shi, H., Baumgartner, M., Camacho, C. J., Smithgall, T. E.
Fluorescence polarization screening assays for small molecule allosteric modulators of ABL kinase function. PLOS ONE, 2015, 10(7), 1–26.

Huynh, T. P., Barwe, S. P., Lee, S. J., McSpadden, R., Franco, O. E., Hayward, S. W., Rajasekaran, A. K.
Glucocorticoids Suppress Renal Cell Carcinoma Progression by Enhancing Na,K-ATPase Beta-1 Subunit Expression. PLOS ONE, 2015 10(4), e0122442.

Keillor, J. W., Apperley, K. Y. P., Akbar, A.
Inhibitors of tissue transglutaminase. Trends in Pharmacological Sciences, 2015, 36(1), 32–40.

Lasserre, J.-P., Dautant, A., Aiyar, R. S., Kucharczyk, R., Glatigny, A., Tribouillard-Tanvier, D., di Rago, J.-P.
Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies. Disease Models & Mechanisms, 2015, 8(6), 509–526.

Malergue, F., van Agthoven, a., Scifo, C., Egan, D., Strous, G. J.
Automation of a Phospho-STAT5 Staining Procedure for Flow Cytometry for Application in Drug Discovery. Journal of Biomolecular Screening, 2015, 20(3), 416–421.

Nath, A. K., Ryu, J. H., Jin, Y. N., Roberts, L. D., Dejam, A., Gerszten, R. E., Peterson, R. T.
PTPMT1 inhibition lowers glucose through succinate dehydrogenase phosphorylation. Cell Reports, 2015, 10(5), 694–701.

Oprea, T. I., Sklar, L. A., Agola, J. O., Guo, Y., Silberberg, M., Roxby, J. Wandinger-Ness, A.
Novel activities of select NSAID renantiomers against Rac1 and Cdc42 GTPases. PLOS ONE, 2015, 10(11), 1–32.

Park, C. Y., Zhou, E. H., Tambe, D., Chen, B., Lavoie, T., Dowell, M., Krishnan, R.
High-throughput screening for modulators of cellular contractile force. Integrative Biology : Quantitative Biosciences from Nano to Macro, 2015, 7(10), 1–16.

Pedram Fatemi, R., Salah-Uddin, S., Modarresi, F., Khoury, N., Wahlestedt, C., Faghihi, M. A.
Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. Journal of Biomolecular Screening, 2015, 20(9), 1132–41.

Porcu, G., Serone, E., De Nardis, V., Di Giandomenico, D., Lucisano, G., Scardapane, M., Ragnini-Wilson, A.
Clobetasol and halcinonide act as smoothened agonists to promote myelin gene expression and RxRγ receptor activation. PLOS ONE, 2015, 10(12), 1–22.

Preuett, B., Leeder, J. S., Abdel-Rahman, S.
Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans. Journal of Biomolecular Screening, 2015, 20(9), 1171–1177.

Raneri, M., Sciandrone, B., Briani, F.
A whole-cell assay for specific inhibitors of translation initiation in bacteria. Journal of Biomolecular Screening, 2015, 20(5), 627–33.

Ratajewski, M., Grzelak, I., Wisniewska, K., Ryba, K., Gorzkiewicz, M., Walczak-Drzewiecka, A., Dastych, J.
Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicology Letters, 2015, 232(1), 193–202.
Rauthan, M., Pilon, M.
A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. Elegans. Worm, 2015, 4(4), e1096490.

Ren, X.-R., Wang, J., Osada, T., Mook, R. A., Morse, M. A., Barak, L. S., Chen, W.
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. Breast Cancer Research, 2015, 17(20), 1–11.

Rybniker, J., Vocat, A., Sala, C., Busso, P., Pojer, F., Benjak, A., Cole, S. T.
Lansoprazole is an antituberculous prodrug targeting cytochrome bc1. Nature Communications, 2015, 6(7659), 1–8.

Seguin, A., Monnier, V. V., Palandri, A., Bihel, F. F., Rera, M., Schmitt, M., Lesuisse, E.
A Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxidative Medicine and Cellular Longevity, 2015, ID 565140, 1–11.

Srivastava, G., Matta, A., Fu, G., Somasundaram, R. T., Datti, A., Walfish, P. G., Ralhan, R.
Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy. Molecular Oncology, 2015, 9, 1720–1735.

Stolp, Z. D., Smurthwaite, C. A., Reed, C., Williams, W., Dharmawan, A., Djaballah, H., Wolkowicz, R.
A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus. Journal of Biomolecular Screening, 2015, 20(5), 616–26.

Takeuchi, M., Yamamoto, T.
Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Experimental Cell Research, 2015, 335(1), 62–67.

Teixeira-Castro, A., Jalles, A., Esteves, S., Kang, S., Da Silva Santos, L., Silva-Fernandes, A., Maciel, P.
Serotonergic signaling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain, 2015, 138, 3221–3237.

Tsai, S. Y., Maass, K., Lu, J., Fishman, G. I., Chen, S., Evans, T.
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling. Stem Cell Reports, 2015, 4, 1089–1102.

Vidalain, P., Lucas-hourani, M.
Activation de la réponse innée antivirale par des inhibiteurs de la biosynthèse des pyrimidines Les surprises d’un criblage, Med Sci, 2015, 30(4), 98–104.

Wasko, M. J., Pellegrene, K. A., Madura, J. D., Surratt, C. K.
A role for fragment-based drug design in developing novel lead compounds for central nervous system targets. Frontiers in Neurology, 2015, 6(SEP), 1–11.

Watari, A., Hashegawa, M., Muangman, T., Yagi, K., Kondoh, M.
Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression. Biotechnology Letters, 2015, 37, 1177–1185.

Yi, N. Y., He, Q., Caligan, T. B., Smith, G. R., Forsberg, L. J., Brenman, J. E., Sexton, J. Z.
Development of a Cell-Based Fluorescence Polarization Biosensor Using Preproinsulin to Identify Compounds That Alter Insulin Granule Dynamics. Assay and Drug Development Technologies, 2015, 13(9), 558–569.

Zeniou, M., Fève, M., Mameri, S., Dong, J., Salomé, C., Chen, W., Heeschen, C.
Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells. PLOS ONE, 2015, 1–35.

Ahn, H. J., Glickman, J. F., Poon, K. L., Zamolodchikov, D., Jno-Charles, O. C., Norris, E. H., Strickland, S.
A novel A-beta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice. J. Exp. Med. , 2014, 211(6), 1049–1062.

Aiyar, R. S., Bohnert, M., Duvezin-Caubet, S., Voisset, C., Gagneur, J., Fritsch, E. S., Steinmetz, L. M.
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Nature Communications, 2014, 5(5585), 1–9.

Alekseev, S., Ayadi, M., Brino, L., Egly, J. M., Larsen, A. K., & Coin, F.
A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the Chemosensitization of tumor cells to platinum. Chemistry and Biology, 2014, 21, 398–407.

Allali-Hassani, A., Kuznetsova, E., Hajian, T., Wu, H., Dombrovski, L., Li, Y., Vedadi, M. A
Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro. Journal of Biomolecular Screening, 2014, 19(6), 928–935.

Andreux, P. a, Mouchiroud, L., Wang, X., Jovaisaite, V., Mottis, A., Bichet, S., Auwerx, J.
A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. Elegans. Scientific Reports, 2014, 4(5285), 1–10.
Baell, J., Walters, M. A.
Chemical con artists foil drug discovery. Nature, 2014, 513, 481–483.

Balsera, B., Mulet, J., Fernández-Carvajal, A., Torre-Martínez, R. D. La, Ferrer-Montiel, A., Hernández-Jiménez, J. G., Criado, M.
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure. European Journal of Medicinal Chemistry, 2014, 86, 724–739.

Bernardo, S. M., Allen, C. P., Waller, A., Young, S. M., Oprea, T., Sklar, L. A., Lee, S. A.
An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicansvirulence-related proteins. PLOS ONE, 2014, 9(10; e110354), 1–11.

Bharadwaj, U., Eckols, T. K., Kolosov, M., Kasembeli, M. M., Adam, a, Torres, D., Tweardy, D. J.
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene, 2014, 34, 1341–1353

Bhuvanagiri, M., Lewis, J., Putzker, K., Becker, J. P., Leicht, S., Krijgsveld, J., Kulozik, A. E.
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion. EMBO Molecular Medicine, 2014, 6(12), 1593–1609.

Blatt, J., Farag, S., Corey, S. J., Sarrimanolis, Z., Muratov, E., Fourches, D., Janzen, W. P.
Expanding the scope of drug repurposing in pediatrics: the Children’s Pharmacy Collaborative Drug Discovery Today, 2014, 19(11), 1696–1698.

Chang, Q., Berdyshev, E., Cao, D., Bogaard, J. D., White, J. J., Chen, S., Grassi, M. A.
Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. Journal of Biological Chemistry, 2014, 289(12), 8337–8352.

Denicolaï, E., Baeza-Kallee, N., Tchoghandjian, A., Carré, M., Colin, C., Jiglaire, C. J., Figarella-Branger, D. Proscillaridin.
A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo. Oncotarget, 2014, 5(21), 10934–10948.

Donohue, E., Balgi, A. D., Komatsu, M., Roberge, M.
Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated proteins by the autophagy inhibitor verteporfin. PLOS ONE, 2014, 9(12), 1–30.

Filgueira, C. S., Benod, C., Lou, X., Gunamalai, P. S., Villagomez, R. A., Strom, A., Webb,
P. A screening cascade to identify ERβ ligands. Nuclear Receptor Signaling, 2014, 12, 1–13.

García-Alcover, I., Colonques-Bellmunt, J., Garijo, R., Tormo, J. R., Artero, R., Álvarez-Abril, M. C., Pérez-Alonso, M.
Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1. Disease Models & Mechanisms, 2014, 7(11), 1297–1306.

Geer, M. A., Fitzgerald, M. C.
Energetics-based methods for protein folding and stability measurements. Annual Review of Analytical Chemistry (Palo Alto, Calif.) , 2014, 7(1), 209–28.

Gutierrez, A., Pan, L., Groen, R. W. J., Baleydier, F., Kentsis, A., Marineau, J., Aster, J. C.
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. Journal of Clinical Investigation, 2014, 124(2), 644–655.

Hall, C. J., Wicker, S. M., Chien, A.-T., Tromp, A., Lawrence, L. M., Sun, X., Crosier, P. S.
Repositioning drugs for inflammatory disease-fishing for new anti-inflammatory agents. Disease Models & Mechanisms, 2014, 7, 1069–1081.

Kawahara, G., Gasperini, M. J., Myers, J. A., Widrick, J. J., Eran, A., Serafini, P. R., Kunkel, L. M.
Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Human Molecular Genetics, 2014, 23(7), 1869–1878.

Liu, C., Lou, W., Zhu, Y., Nadiminty, N., Schwartz, C. T., Evans, C. P., Gao, A. C.
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer. Clinical Cancer Research 2014, (Vol. 20).

Mech, L. D.
Chemical Genetic Identification of the Histamine H1 Receptor as a Stimulator of Insulin-Induced Adipogenesis. Chemistry & Biology, 2014 11, 907–913.

Meneely, K. M., Luo, Q., Riley, A. P., Taylor, B., Roy, A., Stein, R. L., Lamb, A. L.
Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorganic and Medicinal Chemistry, 2014, 22, 5961–5969.
Normand, A., Rivière, E., Renodon-Cornière, A.
Identification and characterization of human Rad51 inhibitors by screening of an existing drug library. Biochemical Pharmacology, 2014, 91, 293–300.

Nylén, F., Miraglia, E., Cederlund, A., Ottosson, H., Strömberg, R., Gudmundsson, G. H., Agerberth, B.
Boosting innate immunity: Development and validation of a cell-based screening assay to identify LL-37 inducers. Innate Immunity, 2014, 20(4), 364–376.

Patten, S. a, Armstrong, G. a B., Lissouba, A., Kabashi, E., Parker, J. A., & Drapeau, P.
Fishing for causes and cures of motor neuron disorders. Disease Models & Mechanisms, 2014, 7, 799–809.

Pytel, D., Seyb, K., Liu, M., Ray, S. S., Concannon, J., Huang, M., Glicksman, M. A.
Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen, 2014, 2(2), 1024–1034.

Röhrig, U. F., Majjigapu, S. R., Chambon, M., Bron, S., Pilotte, L., Colau, D., Michielin, O.
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. European Journal of Medicinal Chemistry, 2014, 84, 284–301.

Tegos, G. P., Evangelisti, A. M., Strouse, J. J., Ursu, O., Bologa, C., Sklar, L. A.
A high throughput flow cytometric assay platform targeting transporter inhibition. Drug Discovery Today: Technologies, 2014, 12, e95–e103.

Theorell, J., Gustavsson, A. L., Tesi, B., Sigmundsson, K., Ljunggren, H. G., Lundbäck, T., Bryceson, Y. T.
Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation. Cancer Immunology, Immunotherapy, 2014, 63, 627–641.

Voisset, C., Daskalogianni, C., Contesse, M.-A., Mazars, A., Arbach, H., Le Cann, M., Blondel, M.
A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus. Disease Models & Mechanisms, 2014, 7, 435–444.

Voisset, C., García-Rodríguez, N., Birkmire, A., Blondel, M., Wellinger, R. E.
Using yeast to model calcium-related diseases: Example of the Hailey-Hailey disease. Biochimica et Biophysica Acta - Molecular Cell Research, 2014, 1843(10), 2315–2321.

Walzl, A., Unger, C., Kramer, N., Unterleuthner, D., Scherzer, M., Hengstschläger, M., Dolznig, H.
The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in Spheroid Screening Assays. Journal of Biomolecular Screening, 2014, 19(7), 1047–1059.

Wang, J., Cheng, H., Ratia, K., Varhegyi, E., Hendrickson, W. G., Li, J., Rong, L.
A Comparative High-Throughput Screening Protocol to Identify Entry Inhibitors of Enveloped Viruses. Journal of Biomolecular Screening, 2014, 19(1), 100–107.

Wolter, J. K., Wolter, N. E., Blanch, A., Partridge, T., Cheng, L., Morgenstern, D. A., Irwin, M. S.
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget, 2014, 5(1), 161–172.

Yang, Y. H. C., Vilin, Y. Y., Roberge, M., Kurata, H. T., Johnson, J. D.
Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death. Molecular Endocrinology, 2014, 28(3), 406–417.

Zhang, M., Luo, G., Zhou, Y., Wang, S., Zhong, Z.
Phenotypic Screens Targeting Neurodegenerative Diseases. Journal of Biomolecular Screening, 2014, 19(1), 1–16.

Podolska, K., Sedlak, D., Bartunek, P., Svoboda, P.
Fluorescence-Based High-Throughput Screening of Dicer Cleavage Activity. Journal of Biomolecular Screening, 2014, 19(3), 417–426.

Ahmad, S., Hughes, M. a, Johnson, G. L., Scott, J. E.
Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. Journal of Biomolecular Screening, 2013, 18(4), 388–399.

Antoniani, D., Rossi, E., Rinaldo, S., Bocci, P., Lolicato, M., Paiardini, A., Landini, P.
The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability. Applied Microbiology and Biotechnology 2013, 97, 7325–7336.

Audran, E., Dagher, R., Gioria, S., Tsvetkov, P. O., Kulikova, A. A., Didier, B., Haiech, J.
A general framework to characterize inhibitors of calmodulin: Use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains. Biochimica et Biophysica Acta - Molecular Cell Research, 2013, 1833(7), 1720–1731.
Bharat, A., Blanchard, J. E., Brown, E. D.
A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor of bacterial ribosome biogenesis. Journal of Biomolecular Screening, 2013, 18(7), 830–836.

Blatt, J., Corey, S. J.
Drug repurposing in pediatrics and pediatric hematology oncology. Drug Discovery Today, 2013, 18(1–2), 4–10.

Cederlund, A., Nylén, F., Miraglia, E., Bergman, P., Gudmundsson, G. H., Agerberth, B.
Label-Free Quantitative Mass Spectrometry Reveals Novel Pathways Involved in LL-37 Expression. Journal of Innate Immunity, 2013, 365–376.

Chartier, A., Simonelig, M.
Animal models in therapeutic drug discovery for oculopharyngeal muscular dystrophy. Drug Discovery Today: Technologies, 2013, 10, e103–e108.

Choulier, L., Nominé, Y., Zeder-Lutz, G., Charbonnier, S., Didier, B., Jung, M. L., Altschuh, D.
Chemical library screening using a SPR-based inhibition in solution assay: Simulations and experimental validation. Analytical Chemistry, 2013, 85, 8787–8795.

Dahlin, J. L., Sinville, R., Solberg, J., Zhou, H., Han, J., Francis, S., Zhang, Z.
A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation. PLOS ONE, 2013, 8(11).

Goldman, R. C.
Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis? Tuberculosis, 2013, 93, 569–588.

Gozalbes, R., Mosulén, S., Ortí, L., Rodríguez-Díaz, J., Carbajo, R. J., Melnyk, P., Pineda-Lucena, A.
Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches. Bioorganic and Medicinal Chemistry, 2013, 21, 1944–1951.

Gupta, V. A., Kuwada, J. Y., Beggs, A. H.
P.4.11 Developing therapies for congenital myopathies by high throughput chemical screening in ryanodine receptor 1 mutant zebrafish. Neuromuscular Disorders, 2013, 23(9–10), 762–763.

Jiang, X., Sun, L., Qiu, J. J., Sun, X., Li, S., Wang, X., Dong, S.
A Novel Application of Furazolidone: Anti-Leukemic Activity in Acute Myeloid Leukemia. PLOS ONE, 2013, 8(8-e72335), 1–9.

Jin, S., Sarkar, K. S., Jin, Y. N., Liu, Y., Kokel, D., Van Ham, T. J., Peterson, R. T.
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. Journal of Biomolecular Screening, 2013, 18(1), 108–115.

Kawahara, G., & Kunkel, L. M.
Zebrafish based small molecule screens for novel DMD drugs. Drug Discovery Today: Technologies, 2013, 10(1), e91–e96.

Kourtesi, C., Ball, A. R., Huang, Y.-Y., Jachak, S. M., Vera, D. M. a, Khondkar, P., Tegos, G. P.
Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation. The Open Microbiology Journal, 2013, 7, 34–52.

Kumagai, H., Suemori, H., Uesugi, M., Nakatsuji, N., Kawase, E.
Identification of small molecules that promote human embryonic stem cell self-renewal. Biochemical and Biophysical Research Communications, 2013, 434, 710–716.

Liu, M., Lin, Y. ling, Chen, X. R., Liao, C. C., Poo, W. K.
In vitro assessment of Macleaya cordata crude extract bioactivity and anticancer properties in normal and cancerous human lung cells. Experimental and Toxicologic Pathology, 2013, 65, 775–787.

McCormick, A. V., Wheeler, J. M., Guthrie, C. R., Liachko, N. F., Kraemer, B. C.
Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biological Psychiatry, 2013, 73, 464–471.

Ozawa, M., Shimojima, M., Goto, H., Watanabe, S., Hatta, Y., Kiso, M., Kawaoka, Y.
A cell-based screening system for influenza A viral RNA transcription/replication inhibitors. Scientific Reports, 3, 2013, 1106.

Reipas, K. M., Law, J. H., Couto, N., Islam, S., Li, Y., Li, H., Dunn, S. E.
Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget, 2013, 4(2), 329–345. Robinson, T. J. W., Liu, J. C., Vizeacoumar, F., Sun, T., Maclean, N., Egan, S. E., Zacksenhaus, E.
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLOS ONE, 2013, 8(11).
Sadikot, T., Swink, M., Eskew, J. D., Brown, D., Zhao, H., Kusuma, B. R., Vielhauer, G. A.
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay and Drug Development Technologies, 2013, 11(8), 478–488.

Salani, B., Marini, C., Rio, A. Del, Ravera, S., Massollo, M., Orengo, A. M., Sambuceti, G.
Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of hexokinase-II. Scientific Reports, 2013, 3 (2070), 1–8.

Shanks, E. J.
Reduce, reuse, recycle: How drug repositioning is finding its niche in drug discovery. European Pharmaceutical Review, 2013, 18(3), 31–34.

Siles, S. A., Srinivasan, A., Pierce, C. G., Lopez-Ribot, J. L., Ramasubramanian, A. K.
High-throughput screening of a collection of known pharmacologically active small compounds for identification of candida albicans biofilm inhibitors. Antimicrobial Agents and Chemotherapy, 2013, 57(8), 3681–3687.

Wrench, A. P., Gardner, C. L., Gonzalez, C. F., Lorca, G. L.
Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis. PLOS ONE, 2013, 8(1 (e54498)), 1–14.

Zeder-Lutz, G., Renau-Ferrer, S., Aguié-Béghin, V., Rakotoarivonina, H., Chabbert, B., Altschuh, D., Rémond, C.
Novel surface-based methodologies for investigating GH11 xylanase-lignin derivative interactions. The Analyst, 2013, 138(22), 6889–99.

Zeidler, U., Bougnoux, M. E., Lupan, A., Helynck, O., Doyen, A., Garcia, Z., d’Enfert, C.
Synergy of the antibiotic colistin with echinocandin antifungals in candida species. Journal of Antimicrobial Chemotherapy, 2013, 68(6), 1285–1296.

Ahmad, S., Hughes, M. A., Yeh, L.-A., Scott, J. E.
Potential Repurposing of Known Drugs as Potent Bacterial -Glucuronidase Inhibitors. Journal of Biomolecular Screening, 2012, 17(7), 957–965.

Colliandre, L., Le Guilloux, V., Bourg, S., Morin-Allory, L.
Visual characterization and diversity quantification of chemical libraries: 2. Analysis and selection of size-independent, subspace-specific diversity indices. Journal of Chemical Information and Modeling, 2012, 52(2), 327–342.

Conesa, C., Doss, M. X., Antzelevitch, C., Sachinidis, A., Sancho, J., Carrodeguas, J. A.
Identification of Specific Pluripotent Stem Cell Death-Inducing Small Molecules by Chemical Screening. Stem Cell Reviews and Reports, 2012, 8, 116–127.

De Chassey, B., Meyniel-Schicklin, L., Aublin-Gex, A., André, P., Lotteau, V.
New horizons for antiviral drug discovery from virus-host protein interaction networks. Current Opinion in Virology, 2012, 2(5), 606–613.

Ding, Z., German, P., Bai, S., Feng, Z., Gao, M., Si, W., Jonasch, E.
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. Journal of Biomolecular Screening, 2012, 17(5), 572–580.

Flusin, O., Saccucci, L., Contesto-Richefeu, C., Hamdi, A., Bardou, C., Poyot, T., Iseni, F.
A small molecule screen in yeast identifies inhibitors targeting protein-protein interactions within the vaccinia virus replication complex. Antiviral Research, 2012, 96(2), 187–195.

Giacomotto, J., Ségalat, L., Carre-Pierrat, M., Gieseler, K.
Caenorhabditis elegans as a chemical screening tool for the study of neuromuscular disorders. Manual and semi-automated methods. Methods, 2012, 56(1), 103–113.

Gupte, J., Swaminath, G., Danao, J., Tian, H., Li, Y., Wu, X.
Signaling property study of adhesion G-protein-coupled receptors. FEBS Letters, 2012, 586, 1214–1219.

Holmes, A. R., Keniya, M. V., Ivnitski-Steele, I., Monk, B. C., Lamping, E., Sklar, L. A., Cannon, R. D.
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial Agents and Chemotherapy, 2012, 56(3), 1508–1515.

Li, Y.-J., Zhao, X., Vecchiarelli-Federico, L. M., Li, Y., Datti, A., Cheng, Y., Ben-David, Y.
Drug-mediated inhibition of Fli-1 for the treatment of leukemia. Blood Cancer Journal, 2012, 2(e54), 1–9.
Libraries, O.
Drug Repurposing development strategy, 2012, 90(40), 1–8. Oprea, T. I., Mestres, J.
Drug Repurposing: Far Beyond New Targets for Old Drugs. The AAPS Journal, 2012, 14(4), 759–763.

Park, S. J., Shin, J. H., Kim, E. S., Jo, Y. K., Kim, J. H., Hwang, J. J., Cho, D. H.
Mitochondrial fragmentation caused by phenanthroline promotes mitophagy. FEBS Letters, 2012, 586(24), 4303–4310.

Polireddy, K., Khan, M. M. T., Chavan, H., Young, S., Ma, X., Waller, A., Krishnamurthy, P. A
Novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. PLOS ONE, 2012, e4005, 7, 1–14.

Reynolds, R. C., Ananthan, S., Faaleolea, E., Hobrath, J. V., Kwong, C. D., Maddox, C., Secrist, J. A.
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. Tuberculosis, 2012, 92(1), 72–83.

Sachlos, E., Risueño, R. M., Laronde, S., Shapovalova, Z., Lee, J. H., Russell, J., Bhatia, M.
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell, 2012, 149, 1284–1297.

Shin, J. H., Park, S. J., Jo, Y. K., Kim, E. S., Kang, H., Park, J. H., Cho, D. H.
Suppression of autophagy exacerbates Mefloquine-mediated cell death. Neuroscience Letters, 2012, 515, 162–167.

Tomasini-Johansson, B. R., Johnson, I. A., Hoffmann, F. M., Mosher, D. F.
Quantitative microtiter fibronectin fibrillogenesis assay: Use in high throughput screening for identification of inhibitor compounds. Matrix Biology, 2012, 31, 360–367.

Villalta-Romero, F., Gortat, A., Herrera, A. E., Arguedas, R., Quesada, J., De Melo, R. L., Pérez-Payá, E.
Identification of new snake venom metalloproteinase inhibitors using compound screening and rational peptide design. ACS Medicinal Chemistry Letters, 2012, 3, 540–543.

Walker, S. R., Frank, D. a.
Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets. Jak-Stat, 2012, 1(4), 292–299.

Wang, Y., Davidow, L., Arvanites, A. C., Blanchard, J., Lam, K., Xu, K., McMahon, A. P.
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chemistry and Biology, 2012, 19(8), 972–982.

Zeder-Lutz, G., Choulier, L., Besse, M., Cousido-Siah, A., Figueras, F. X. R., Didier, B., Altschuh, D.
Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders. Analytical Biochemistry, 2012, 421(2), 417–427.

Ahmad, S., Hughes, M. a, Lane, K. T., Redinbo, M. R., Yeh, L.-A., Scott, J. E.
A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors. Current Chemical Genomics, 2011, 5, 13–20.

Allen, J. A., Roth, B. L.
Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annual Review of Pharmacology and Toxicology, 2011, 51, 117–144.

Chen, M. H., Yang, W. L. R., Lin, K. T., Liu, C. H., Liu, Y. W., Huang, K. W., Huang, C. Y. F.
Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma. PLOS ONE, 2011, 6(11).

Chigaev, A., Wu, Y., Williams, D. B., Smagley, Y., Sklar, L. A.
Discovery of Very Late Antigen-4 (VLA-4, α4β 1 integrin) allosteric antagonists. Journal of Biological Chemistry, 2011, 286(7), 5455–5463.

Chopra, S., Matsuyama, K., Hutson, C., Madrid, P.
Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae. Journal of Antimicrobial Chemotherapy, 2011, 66, 1533–1536.

Couplan, E., Aiyar, R. S., Kucharczyk, R., Kabala, A., Ezkurdia, N., Gagneur, J., Blondel, M.
A yeast-based assay identifies drugs active against human mitochondrial disorders. PNAS USA, 2011, 108(29), 11989–11994.

Dengler, M. A., Staiger, A. M., Gutekunst, M., Hofmann, U., Doszczak, M., Scheurich, P., van der Kuip, H.
Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis. PLOS ONE, 2011, 6(9).
Dey, R., Chen, L.
In search of allosteric modulators of α7-nAChR by solvent density guided virtual screening. Journal of Biomolecular Structure & Dynamics, 2011, 28(5), 695–715.

Ekins, S., Williams, A. J., Krasowski, M. D., Freundlich, J. S.
In silico repositioning of approved drugs for rare and neglected diseases. Drug Discovery Today, 2011, 16(7–8), 298–310.

Fonslow, B. R., Stein, B. D., Webb, K. J., Xu, T., Choi, J., Kyu, S., Iii, J. R. Y.
A High Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription Factors, 2011, 10(1), 54–56.

Gohil, V. M., Offner, N., Walker, J. A., Sheth, S. A., Fossale, E., Gusella, J. F., Mootha, V. K.
Meclizine is neuroprotective in models of Huntington’s disease. Human Molecular Genetics, 2011, 20(2), 294–300.

Hubert Jr, L., Lin, Y., Dion, V., Wilson, J. H.
Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells. Molecular and Cellular Biology, 2011, 31(15), 3105–3112.

Hundeshagen, P., Hamacher-Brady, A., Eils, R., Brady, N. R.
Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy. BMC Biology, 2011, 9(1), 38.

Jo, Y. K., Park, S. J., Shin, J. H., Kim, Y., Hwang, J. J., Cho, D. H., Kim, J. C.
ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. Biochemical and Biophysical Research Communications, 2011, 404(4), 1039–1043.

Kawahara, G., Karpf, J.
Drug screening in a zebrafish model of Duchenne muscular dystrophy. Pnas, 2011, 108(13), 5331–6.

Kawahara, G., Karpf, J. A., Myers, J. A., Alexander, M. S., Guyon, J. R., Kunkel, L. M.
Drug screening in a zebrafish model of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(13), 5331–6.

Kumar, E. A., Charvet, C. D., Lokesh, G. L., Natarajan, A.
High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions. Analytical Biochemistry, 2011, 411(2), 254–260.

Le Guilloux, V., Colliandre, L., Bourg, S., Guénegou, G., Dubois-Chevalier, J., Morin-Allory, L.
Visual characterization and diversity quantification of chemical libraries: 1. Creation of delimited reference chemical subspaces. Journal of Chemical Information and Modeling, 2011, 51(8), 1762–1774.

Lee, Y. J., Burlet, E., Wang, S., Xu, B., Huang, S., Galiano, F. J., Witt, S. N.
Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochemical and Biophysical Research Communications, 2011, 414(1), 205–208.

MacKenzie, A. E., Lappin, J. E., Taylor, D. L., Nicklin, S. A., Milligan, G.
GPR35 as a novel therapeutic target. Frontiers in Endocrinology, 2011, 1–10.

Milligan, G.
Orthologue selectivity and ligand bias: Translating the pharmacology of GPR35. Trends in Pharmacological Sciences, 2011, 32(5), 317–325.

Moorwood, C., Lozynska, O., Suri, N., Napper, A. D., Diamond, S. L., Khurana, T. S.
Drug discovery for duchenne muscular dystrophy via utrophin promoter activation screening. PLOS ONE, 2011, 6(10), 1–11.

Peal, D. S., Mills, R. W., Lynch, S. N., Mosley, J. M., Lim, E., Ellinor, P. T., Milan, D. J.
Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation, 2011, 123(1), 23–30.

Sexton, J. Z., Danshina, P. V, Lamson, D. R., Hughes, M., House, A. J., Yeh, L.-A., Williams, K. P.
Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS). Current Chemical Genomics, 2011, 5, 30–41.

Spitzer, M., Griffiths, E., Blakely, K. M., Wildenhain, J., Ejim, L., Rossi, L., Wright, G. D.
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Molecular Systems Biology, 2011, 7(1), 499.

Takakura, A., Nelson, E. A., Haque, N., Humphreys, B. D., Zandi-Nejad, K., Frank, D. A., Zhou, J.
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Human Molecular Genetics, 2011, 20(21), 4143–4154.
Andrews, P. D., Becroft, M., Aspegren, A., Gilmour, J., James, M. J., McRae, S., Andrews, P. W.
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. The Biochemical Journal, 2010, 432(1), 21–33.

Antoniani, D., Bocci, P., MacIa̧g, A., Raffaelli, N., & Landini, P.
Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors. Applied Microbiology and Biotechnology, 2010, 85(4), 1095–1104.

Barbaric, I., Gokhale, P. J., Jones, M., Glen, A., Baker, D., & Andrews, P. W.
Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies. Stem Cell Research, 2010, 5(2), 104–119.

Buckley, C. E., Marguerie, A., Roach, A. G., Goldsmith, P., Fleming, A., Alderton, W. K., Franklin, R. J. M.
Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology, 2010, 59(3), 149–159.

Carme Mulero, M., Orzaez, M., Messeguer, J., Messeguer, A., Pérez-Paya, E., Pérez-Riba, M. A
Fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex. Analytical Biochemistry, 2010, 398(1), 99–103.

Colton, C. K., Kong, Q., Lai, L., Zhu, M. X., Seyb, K. I., Cuny, G. D., Glenn Lin, C.-L.
Identification of Translational Activators of Glial Glutamate Transporter EAAT2 through Cell-Based High-Throughput Screening: An Approach to Prevent Excitotoxicity. Journal of Biomolecular Screening, 2010, 15(6), 653–662.

Dearmond, P. D., West, G. M., Anbalagan, V., Campa, M. J., Patz, E. F., Fitzgerald, M. C.
Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. Journal of Biomolecular Screening, 2010, 15(9), 1051–62.

Doughty-Shenton, D., Joseph, J. D., Zhang, J., Pagliarini, D. J., Kim, Y., Lu, D., Casey, P. J.
Pharmacological targeting of the mitochondrial phosphatase PTPMT1. The Journal of Pharmacology and Experimental Therapeutics, 2010 333(2), 584–92.

Feng, R., Rios, J. A., Onishi, T., Lokshin, A., Gorelik, E., Lentzsch, S.
Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leukemia Research, 2010, 34(7), 917–924.

Gui, C., Obaidat, A., Chaguturu, R., Hagenbuch, B.
Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Current Chemical Genomics, 2010, 4, 1–8.

Insa, R.
Drug Repositioning: Filling the Gap. European Biopharmaceutical Review, 2010 retrieved from

Jadhav, A., Ferreira, R. S., Klumpp, C., Mott, B. T., Austin, C. P., Inglese, J., Simeonov, A.
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. Journal of Medicinal Chemistry, 2010, 53(1), 37–51.

Jasenosky, L. D., Neumann, G., Kawaoka, Y.
Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. Antimicrobial Agents and Chemotherapy, 54(7), 2010, 3007–3010.

Johnson, R. M., Allen, C., Melman, S. D., Waller, A., Young, S. M., Sklar, L. A., Parra, K. J.
Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Analytical Biochemistry, 2010, 398(2), 203–211.

Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C. Y., Mateus, R., Peterson, R. T.
Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol, 2010, 6(3), 231–237.

Kuhn, I., Kellenberger, E., Said-Hassane, F., Villa, P., Rognan, D., Lobstein, A., Muller-Steffner, H.
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme. Bioorganic and Medicinal Chemistry, 2010, 18(22), 7900–7910.

Leonardi, R., Zhang, Y. M., Yun, M. K., Zhou, R., Zeng, F. Y., Lin, W., Jackowski, S.
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chemistry and Biology, 2010, 17(8), 892–902.

Lipinski, R. J., Bushman, W.
Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening. Toxicology in Vitro, 2010 24(5), 1404–1409.
Manuscript, A., & Leads, P. D. NIH Public Access. Tuberculosis, 2010, 89(5), 331–333.

Manuscript, A., & Syndromes, G. P. NIH Public Access, 2010, 48(Suppl 2), 1–6.

Ouertatani-Sakouhi, H., Liu, M., El-Turk, F., Cuny, G. D., Glicksman, M. A., Lashuel, H. A.
Kinetic-Based High-Throughput Screening Assay to Discover Novel Classes of Macrophage Migration Inhibitory Factor Inhibitors. Journal of Biomolecular Screening, 2010, 15(4), 347–358.

Peluso, J., Muller, C. D.
Advances in flow cytometry for drug screening. Expert Opinion on Drug Discovery, 2010, 5(9), 827–833. 10.1517/17460441.2010.509395

Rodgers, A. D., Zhu, H., Fourches, D., Rusyn, I., Tropsha, A., Hill, C., Carolina, N.
Modeling Liver-Related Adverse Effects of Drugs Using k Nearest Neighbor Quantitative Structure - Activity Relationship Method. Chemical Research in Toxicology, 2010, 23, 724–732.

Schaertl, S., Prime, M., Wityak, J., Dominguez, C., Munoz-Sanjuan, I., Pacifici, R. E., Macdonald, D.
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. Journal of Biomolecular Screening : The Official Journal of the Society for Biomolecular Screening, 2010, 15(5), 478–487.

Shahinas, D., Liang, M., Datti, A., Pillai, D. R.
A repurposing strategy identifies novel synergistic inhibitors of plasmodium falciparum heat shock protein 90. Journal of Medicinal Chemistry, 2010, 53(9), 3552–3557.

Shum, D., Smith, J. L., Hirsch, A. J., Bhinder, B., Radu, C., Stein, D. A., Djaballah, H.
High-content assay to identify inhibitors of dengue virus infection. Assay and Drug Development Technologies, 2010, 8(5), 553–70.

Talele, T. T., Arora, P., Kulkarni, S. S., Patel, M. R., Singh, S., Chudayeu, M., Kaushik-Basu, N.
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry, 2010, 18(13), 4630–4638.

Vedadi, M., Arrowsmith, C. H., Allali-Hassani, A., Senisterra, G., Wasney, G. A.
Biophysical characterization of recombinant proteins: A key to higher structural genomics success. Journal of Structural Biology, 2010, 172(1), 107–119.

Yeyeodu, S. T., Witherspoon, S. M., Gilyazova, N., Ibeanu, G. C.
A rapid, inexpensive high throughput screen method for neurite outgrowth. Current Chemical Genomics, 2010, 4, 74–83.

Zhao, P., Sharir, H., Kapur, A., Cowan, A., Geller, E. B., Adler, M. W., Abood, M. E.
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Molecular Pharmacology, 2010, 78(4), 560–568.

Ananthan, S., Faaleolea, E. R., Goldman, R. C., Hobrath, J. V., Kwong, C. D., Laughon, B. E., White, E. L.
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis, 89(5), 2009, 334–353.

Auld, D. S., Zhang, Y. Q., Southall, N. T., Rai, G., Landsman, M., MacLure, J., Inglese, J. A
basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. Journal of Medicinal Chemistry, 2009, 52(5), 1450–1458.

Calmels, N., Seznec, H., Villa, P., Reutenauer, L., Hibert, M., Haiech, J., Puccio, H.
Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen. BMC Neurology, 2009, 9(1), 46.

Charpentier, X., Gabay, J. E., Reyes, M., Zhu, J. W., Weiss, A., Shuman, H. A.
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathogens, 2009, 5(7).

Chen, S., Borowiak, M., Fox, J. L., Maehr, R., Osafune, K., Davidow, L., Melton, D.
A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature Chemical Biology, 2009, 5(4), 258–265.

Conn, P. J., Jones, C. K., Lindsley, C. W.
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends in Pharmacological Sciences, 2009 30(3), 148–155.
Damoiseaux, R., Sherman, S. P., Alva, J. a, Peterson, C., Pyle, A. D.
Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells. Stem Cells, 2009, 27(3), 533–542.

D’Elia, M. A., Millar, K. E., Bhavsar, A. P., Tomljenovic, A. M., Hutter, B., Schaab, C., Brown, E. D.
Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis. Chemistry and Biology, 2009, 16(5), 548–556.

Du, L., Damoiseaux, R., Nahas, S., Gao, K., Hu, H., Pollard, J. M., Gatti, R.
Nonaminoglycoside compounds induce readthrough of nonsense mutations. The Journal of Experimental Medicine, 2009, 206(10), 2285–2297.

Ewald, J. A., Peters, N., Desotelle, J. A., Hoffmann, F. M., & Jarrard, D. F.
A High-Throughput Method to Identify Novel Senescene-Inducing Compounds. J Biomol Screen, 2009, 14(7), 853–858.

Gozalbes, R., Mosulén, S., Carbajo, R. J., & Pineda-Lucena, A.
Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors. Journal of Computer-Aided Molecular Design, 2009, 23(8), 555–569.

Haiech, J., Heizmann, C. W., & Krebs, J.
The 10th European symposium on calcium-binding proteins in normal and transformed cells. Biochimica et Biophysica Acta, 2009, 1793(6), 931–2.

Haynes, M. K., Strouse, J. J., Waller, A., Leitao, A., Curpan, R. F., Bologa, C., Thompson, T. A.
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. Journal of Biomolecular Screening, 2009, 14(6), 596–609.

Hibert, M. F.
French/European academic compound library initiative. Drug Discovery Today, 2009, 14(15–16), 723–725.

Huang, X., Setola, V., Yadav, P. N., Allen, J. a, Rogan, S. C., Hanson, B. J., Roth, B. L
Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine 2B Receptor Agonists : Implications for Drug Safety Assessment. Molecular Pharmacology, 2009, 5(4), 710–722.

Iorns, E., Lord, C. J., & Ashworth, A.
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. The Biochemical Journal, 2009, 417, 361–370.

Kemmer, D., McHardy, L. M., Hoon, S., Rebérioux, D., Giaever, G., Nislow, C., Roberge, M.
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. BMC Microbiology, 2009, 9(1), 9.

Lagunin, A., Filimonov, D., Zakharov, A., Xie, W., Huang, Y., Zhu, F., Poroikov, V.
Computer-aided prediction of rodent carcinogenicity by PASS and CISOC-PSCT. QSAR and Combinatorial Science, 2009, 28(8), 806–810.

Langer, T., Hoffmann, R., Bryant, S., Lesur, B.
Hit finding: towards “smarter” approaches. Current Opinion in Pharmacology, 2009, 9(5), 589–593.

Larsen, R. S., Zylka, M. J., & Scott, J. E.
A high throughput assay to identify small molecule modulators of prostatic acid phosphatase. Current Chemical Genomics, 2009, 3, 42–9.

Livingstone, M., Larsson, O., Sukarieh, R., Pelletier, J., Sonenberg, N.
A Chemical Genetic Screen for mTOR Pathway Inhibitors Based on 4E-BP-Dependent Nuclear Accumulation of eIF4E. Chemistry and Biology, 2009, 16(12), 1240–1249.

MacArthur, R., Leister, W., Veith, H., Shinn, P., Southall, N., Austin, C. P., Auld, D. S.
Monitoring Compound Integrity with cytochrome P450 assays and qHTS., 2009, 1–9.

Manuscript, A., & Formation, H. T. F. NIH Public Access, 2009, 358(1), 1–6.

Mulero, M. C., Aubareda, A., Orzáez, A., Messeguer, J., Serrano-Candelas, E., Martínez-Hoyer, S., Pérez-Riba, M.
Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. Journal of Biological Chemistry, 2009, 284(14), 9394–9401.

Norton, J. T., Titus, S. A., Dexter, D., Austin, C. P., Zheng, W., Huang, S.
Automated high-content screening for compounds that disassemble the perinucleolar compartment. Journal of Biomolecular Screening, 2009, 14(9), 1045–1053.
Orzáez, M., Mondragón, L., García-Jareño, A., Mosulén, S., Pineda-Lucena, A., Pérez-Payá, E. (2009).
Deciphering the antitumoral activity of quinacrine: Binding to and inhibition of Bcl-xL. Bioorganic and Medicinal Chemistry Letters, 2009, 19(6), 1592–1595.

Perne, A., Muellner, M. K., Steinrueck, M., Craig-Mueller, N., Mayerhofer, J., Schwarzinger, I., Mayerhofer, M.
Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. PLOS ONE, 2009, 4(12).

Porotto, M., Orefice, G., Yokoyama, C. C., Mungall, B. A., Realubit, R., Sganga, M. L., Moscona, A.
Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. Journal of Virology, 2009, 83(10), 5148–5155.

Pyeon, D., Pearce, S. M., Lank, S. M., Ahlquist, P., Lambert, P. F.
Establishment of human papillomavirus infection requires cell cycle progression. PLoS Pathogens, 2009, 5(2).

Sanders, B. D., Jackson, B., Brent, M., Taylor, A. M., Dang, W., Berger, S. L., Marmorstein, R.
Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorganic and Medicinal Chemistry, 2009, 17(19), 7031–7041.

Sung, J. C., Jensen, N. H., Kurome, T., Kadari, S., Manzano, M. L., Malberg, J. E., Kozikowski, A. P.
Selective 5-hydroxytryptamine 2c receptor agonists derived from the lead compound tranylcypromine: Identification of drugs with antidepressant-like action. Journal of Medicinal Chemistry, 2009, 52(7), 1885–1902.

Wible, B. A.
Incidence and specificity of drug-induced trafficking inhibition of cardiac ion channels. Journal of Pharmacological and Toxicological Methods, 2009, 60(2), 223.

Zhu, P. J., Hobson, J. P., Southall, N., Qiu, C., Thomas, C. J., Lu, J., Liu, S.
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic and Medicinal Chemistry, 2009, 17(14), 5139–5145.

Cascales, L., Mas-Moruno, C., Tamborero, S., Aceña, J. L., Sanz-Cervera, J. F., Fustero, S., Pérez-Payá, E.
Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-α production in the cell. Chemical Biology and Drug Design, 2008, 72(4), 320–328.

Desbordes, S. C., Placantonakis, D. G., Ciro, A., Socci, N. D., Lee, G., Djaballah, H., Studer, L.
High-Throughput Screening Assay for the Identification of Compounds Regulating Self-Renewal and Differentiation in Human Embryonic Stem Cells. Cell Stem Cell, 2008, 2(6), 602–612.

Garcia-Lopez, A., Monferrer, L., Garcia-Alcover, I., Vicente-Crespo, M., Alvarez-Abril, M. C., Artero, R. D.
Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLOS ONE, 2008, 3(2).

Hoffmann, H. H., Palese, P., Shaw, M. L.
Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity. Antiviral Research, 2008, 80(2), 124–134.

Hutchinson, D., Ho, V., Dodd, M., Dawson, H. N., Zumwalt, A. C., Colton, C. A.
NIH Public Access, 2008, 148(4), 825–832.

Ivnitski-Steele, I., Larson, R. S., Lovato, D. M., Khawaja, H. M., Winter, S. S., Oprea, T. I., Edwards, B. S.
High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters. Assay and Drug Development Technologies, 2008, 6(2), 263–276.

Johnson, R. L., Huang, W., Jadhav, A., Austin, C. P., Inglese, J., Martinez, E. D.
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Analytical Biochemistry, 2008, 375(2), 237–248.

Krysan, D. J., Didone, L.
A High-Throughput Screening Assay for Small Molecules, Journal of Biomolecular Screening, 2008, 13(7), 657–664.

Lai, T. S., Liu, Y., Tucker, T., Daniel, K. R., Sane, D. C., Toone, E., Greenberg, C. S.
Identification of Chemical Inhibitors to Human Tissue Transglutaminase by Screening Existing Drug Libraries. Chemistry and Biology, 2008, 15(9), 969–978.

Mangat, C. S., Brown, E. D.
Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE. Chemistry and Biology, 2008, 15(12), 1287–1295.
Nakamura, K., Zawistowski, J. S., Hughes, M. a, Sexton, J. Z., Yeh, L.-A., Johnson, G. L., Scott, J. E.
Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization. Journal of Biomolecular Screening, 2008, 13(5), 396–405.

Patnaik, D., Xian, J.
Molecule Inhibitors of the Mitotic Kinase Haspin By High-Throughput Screening Using a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer Assay. Journal of Biomolecular Screening, 2008, 13(10), 1025–1034.

Senisterra, G. a, Soo Hong, B., Park, H.-W., Vedadi, M.
Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands. Journal of Biomolecular Screening, 2008, 13(5), 337–42.

Seyb, K. I., Schuman, E. R., Ni, J., Huang, M., Michaelis, M. L., Glicksman, M. A.
Identification of Small Molecule Inhibitors of β–Amyloid Cytotoxicity through a Cell-based High-Throughput Screening Platform. Journal of Biomolecular Screening, 2008, 13(9), 870–878.

Simeonov, A., Jadhav, A., Sayed, A. A., Wang, Y., Nelson, M. E., Thomas, C. J., Austin, C. P.
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Neglected Tropical Diseases, 2008, 2(1).

Simeonov, A., Jadhav, A., Thomas, C. J., Wang, Y., Huang, R., Southall, N. T., Inglese, J.
Fluorescence spectroscopic profiling of compound libraries. Journal of Medicinal Chemistry, 2008, 51(8), 2363–2371.

Simeonov, A., Yasgar, A., Jadhav, A., Lokesh, G. L., Klumpp, C., Michael, S., Inglese, J.
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Analytical Biochemistry, 2008, 375(1), 60–70.

Stoilov, P., Lin, C.-H., Damoiseaux, R., Nikolic, J., Black, D. L.
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proceedings of the National Academy of Sciences, 2008, 105(32), 11218–11223.

Tribouillard-Tanvier, D., Béringue, V., Desban, N., Gug, F., Bach, S., Voisset, C., Blondel, M.
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLOS ONE, 2008, 3(4).

Winter, S. S., Lovato, D. M., Khawaja, H. M., Edwards, B. S., Steele, I. D., Young, S. M., Larson, R. S.
High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent. Journal of Biomolecular Screening, 2008, 13(3), 185–93.

Wu, Z., Liu, D., Sui, Y.
Quantitative assessment of hit detection and confirmation in single and duplicate high-throughput screenings. Journal of Biomolecular Screening, 2008, 13(2), 159–67.

Xu, G. W., Mawji, I. A., Macrae, C. J., Koch, C. A., Datti, A., Wrana, J. L., Schimmer, A. D. A
High-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis, 2008, 13(3), 413–422.

Antczak, C., Shum, D., Escobar, S., Bassit, B., Seshan, V. E., Wu, N., Djaballah, H.
High-Troughput Identification of Inhibitors of Human Mitochondrial Peptide Deformylase. J. Biomol. Screen, 2007, 12(4), 521–535.

Azzaoui, K., Hamon, J., Faller, B., Whitebread, S., Jacoby, E., Bender, A., Urban, L.
Modeling promiscuity based on in vitro safety pharmacology profiling data. ChemMedChem, 2007, 2(6), 874–880.

Bender, A., Scheiber, J., Glick, M., Davies, J. W., Azzaoui, K., Hamon, J., Jenkins, J. L.
Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. ChemMedChem, 2007, 2(6), 861–873.

Breger, J., Fuchs, B. B., Aperis, G., Moy, T. I., Ausubel, F. M., Mylonakis, E.
Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathogens, 2007, 3(2), 0168–0178.

Chong, C., Sullivan, D. J.
New uses for old drugs. Nature, 2007, 448(7154), 645.\nhttp://www.nature(...)

Crisman, T. J., Parker, C. N., Jenkins, J. L., Scheiber, J., Thoma, M., Kang, Z. Bin, Glick, M.
Understanding false positives in reporter gene assays: In silico chemogenomics approaches to prioritize cell-based HTS data. Journal of Chemical Information and Modeling, 2007, 47(4), 1319–1327.
Crowe, A., Ballatore, C., Hyde, E., Trojanowski, J. Q., Lee, V. M.-Y.
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochemical and Biophysical Research Communications, 2007, 358(1), 1–6.

Davis, R. E., Zhang, Y.-Q., Southall, N., Staudt, L. M., Austin, C. P., Inglese, J., Auld, D. S. A
Cell-Based Assay for I κ B α Stabilization Using A Two-Color Dual Luciferase-Based Sensor. ASSAY and Drug Development Technologies, 2007, 5(1), 85–104.

Donahue, C. P., Ni, J., Rozners, E., Glicksman, M. a., Wolfe, M. S.
Identification of Tau Stem Loop RNA Stabilizers. Journal of Biomolecular Screening, 2007, 12(6), 789–799.

Donahue, C. P., Ni, J., Rozners, E., Glicksman, M. a., Wolfe, M. S.
Identification of Tau Stem Loop RNA Stabilizers. Journal of Biomolecular Screening, 2007, 12(6), 789–799.

Feng, B. Y., Simeonov, A., Jadhav, A., Babaoglu, K., Inglese, J., Shoichet, B. K., Austin, C. P. A
High-throughput screen for aggregation-based inhibition in a large compound library. Journal of Medicinal Chemistry, 2007, 50(10), 2385–2390.

Fischer, H., Kansy, M., Avdeef, A., & Senner, F.
Permeation of permanently positive charged molecules through artificial membranes-Influence of physico-chemical properties. European Journal of Pharmaceutical Sciences, 2007, 31(1), 32–42.

Honson, N. S., Johnson, R. L., Huang, W., Inglese, J., Austin, C. P., Kuret, J.
Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiology of Disease, 2007, 28(3), 251–260.

Hurtado-Guerrero, R., van Aalten, D. M. F.
Structure of Saccharomyces cerevisiae Chitinase 1 and Screening-Based Discovery of Potent Inhibitors. Chemistry and Biology, 2007, 14(5), 589–599.

Ivey, F. D., Wang, L., Demirbas, D., Allain, C., Hoffman, C. S.
Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases. Journal of Biomolecular Screening, 2007, 13(1), 62–71.

Rezza, G., Nicoletti, L., Angelini, R., Romi, R., Finarelli, A., Panning, M., Cassone, A.
Infection with chikungunya virus in Italy: an outbreak in a temperate region. The Lancet, 2007, 370(9602), 1840–1846.

Sprous, D. G., Salemme, F. R.
A comparison of the chemical properties of drugs and FEMA/FDA notified GRAS chemical compounds used in the food industry. Food and Chemical Toxicology, 2007, 45(8), 1419–1427.

Tsetsarkin, K. A., Vanlandingham, D. L., Mcgee, C. E., Higgs, S.
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential, PLOS Phatogens, 2007, 3(12).

White, E. L., Southworth, K., Ross, L., Cooley, S., Gill, R. B., Sosa, M. I., Fletcher, T. M. A
Novel Inhibitor of Mycobacterium tuberculosis. Journal of Biomolecular Screening, 2007, 100–105.

Bandyopadhyay, S.
A High-Throughput Drug Screen Targeted to the 5’Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA. Journal of Biomolecular Screening, 2007, 11(5), 469–480.

Broom, W. J., Auwarter, K. E., Ni, J., Russel, D. E., Yeh, L.-A., Maxwell, M. M., Brown, R. H.
Two approaches to drug discovery in SOD1-mediated ALS. Journal of Biomolecular Screening, 2006, 11(7), 729–35.

Dagher, R., Pigault, C., Bonnet, D., Boeglin, D., Pourbaix, C., Kilhoffer, M. C., Haiech, J.
Use of a fluorescent polarization based high throughput assay to identify new Calmodulin ligands. Biochimica et Biophysica Acta - Molecular Cell Research, 2006, 1763(11), 1250–1255.

Fara, D. C., Oprea, T. I., Prossnitz, E. R., Bologa, C. G., Edwards, B. S., Sklar, L. A.
Integration of virtual and physical screening. Drug Discovery Today: Technologies, 2006, 3(4), 377–385.

Hergenrother, P. J.
Obtaining and screening compound collections: a user’s guide and a call to chemists. Current Opinion in Chemical Biology, 2006, 10(3), 213–218.

Inglese, J., Auld, D. S., Jadhav, A., Johnson, R. L., Simeonov, A., Yasgar, A., Austin, C. P.
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(7), 11473–11478.

Kinobe, R. T., Dercho, R. a, Vlahakis, J. Z., Brien, J. F., Szarek, W. A, Nakatsu, K.
Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. The Journal of Pharmacology and Experimental Therapeutics, 2006, 319(1), 277–284.

Monge, A., Arrault, A., Marot, C., Morin-Allory, L.
Managing, profiling and analyzing a library of 2.6 million compounds gathered from 32 chemical providers. Molecular Diversity, 2006, 10(3), 389–403.
Ogawa, Y., Mizumoto, N., Tanaka, H., Matsushima, H., Takashima, A.
Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. J Invest Dermatol, 2006, 126(2), 349–353.

Peters, U., Cherian, J., Kim, J. H., Kwok, B. H., Kapoor, T. M.
Probing cell-division phenotype space and Polo-like kinase function using small molecules. Nature Chemical Biology, 2006, 2(11), 618–626.

Schuffenecker, I., Iteman, I., Michault, A., Murri, S., Frangeul, L., Vaney, M. C., Brisse, S.
Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Medicine, 2006, 3(7), 1058–1070.

Severson, W. E., Shindo, N., Sosa, M., Fletcher, T., White, E. L., Ananthan, S., Jonsson, C. B.
Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its Application in Screening of a 100,000-Compound Library. Journal of Biomolecular Screening, 2006, 12(1), 33–40.

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M., Ferguson, M. A. J.
Identification of novel inhibitors of UDP-Glc 4’-epimerase, a validated drug target for african sleeping sickness. Bioorganic and Medicinal Chemistry Letters, 2006, 16(22), 5744–5747.

Wang, J. K. T., Portbury, S., Thomas, M. B., Barney, S., Ricca, D. J., Morris, D. L., Lo, D. C.
Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(27), 10461–6.

Wu, X., Zhong, H., Song, J., Damoiseaux, R., Yang, Z., Lin, S.
Mycophenolic acid is a potent inhibitor of angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2006, 26(10), 2414–2416.

Yip, K. W., Mao, X., Au, P. Y. B., Hedley, D. W., Chow, S., Dalili, S., Liu, F. F.
Benzethonium chloride: A novel anticancer agent identified by using a cell-based small-molecule screen. Clinical Cancer Research, 2006, 12(18), 5557–5569.

Yip, K. W., Ito, E., Mao, X., Au, P. Y. B., Hedley, D. W., Mocanu, J. D., Liu, F.-F.
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Molecular Cancer Therapeutics, 2006, 5(9), 2234–40.

Zotchev, S. B., Stepanchikova, A. V., Sergeyko, A. P., Sobolev, B. N., Filimonov, D. A., Poroikov, V. V.
Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases. Journal of Medicinal Chemistry, 2006, 49(6), 2077–2087.

Bakshi, P., Liao, Y.-F., Gao, J., Ni, J., Stein, R., Yeh, L.-A., Wolfe, M. S.
A High-Throughput Screen to Identify Inhibitors of Amyloid beta-Protein Precursor Processing. Journal of Biomolecular Screening, 2005, 10(1), 1–12.

Case, A., Ni, J., Yeh, L. A., Stein, R. L.
Development of a mechanism-based assay for tissue transglutaminase - Results of a high-throughput screen and discovery of inhibitors. Analytical Biochemistry, 2005, 338(2), 237–244.

Edwards, B. S., Bologa, C., Young, S. M., Balakin, K. V, Prossnitz, E. R., Savchuck, N. P., Oprea, T. I.
Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide. Molecular Pharmacology, 2005, 68(5), 1301–1310.

Mizumoto, N., Gao, J., Matsushima, H., Ogawa, Y., Tanak a, H., Takashima, A.
Discovery of novel immunostimulants by dendritic-cell – based functional screening. Blood, 2005, 106(9), 3082–3090.

O’Connor, K. A., Roth, B. L.
Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery. Nat Rev Drug Discov, 2005, 4(12), 1005–1014.

Rao, F. V., Andersen, O. A., Vora, K. A., DeMartino, J. A., Van Aalten, D. M. F.
Methylxanthine drugs are chitinase inhibitors: Investigation of inhibition and binding modes. Chemistry and Biology, 2005, 12(9), 973–980.

Ray, S. S., Nowak, R. J., Brown, R. H., Lansbury, P. T.
Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(10), 3639–3644.

Razonable, R. R., Henault, M., Watson, H. L., Paya, C. V.
Nystatin induces secretion of interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism. Antimicrobial Agents and Chemotherapy, 2005, 49(8), 3546–3549.

Wible, B. A., Hawryluk, P., Ficker, E., Kuryshev, Y. A., Kirsch, G., Brown, A. M. HERG-Lite®:
A novel comprehensive high-throughput screen for drug-induced hERG risk. Journal of Pharmacological and Toxicological Methods, 2005, 52(1), 136–145.

Young, S. M.
High-Throughput Screening with HyperCyt(R) Flow Cytometry to Detect Small Molecule Formylpeptide Receptor Ligands. Journal of Biomolecular Screening, 2005, 10(4), 374–382.

Ahn, J. S.
Development of an Assay to Screen for Inhibitors of Tau Phosphorylation by Cdk5. Journal of Biomolecular Screening, 2004, 9(2), 122–131.

Doan, T.
High-throughput target validation in model organisms. Drug Discovery Today: TARGETS, 2004, 3(5), 191–197.

Edwards, B. S., Oprea, T., Prossnitz, E. R., Sklar, L. A.
Flow cytometry for high-throughput, high-content screening. Current Opinion in Chemical Biology, 2004, 8(4), 392–398.

Gaud, A., Simon, J. M., Witzel, T., Carre-Pierrat, M., Wermuth, C. G., & Ségalat, L.
Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans. Neuromuscular Disorders, 2004, 14(6), 365–370.

Wermuth, C. G.
Selective Optimization of Side Activities: Another Way for Drug Discovery. Journal of Medicinal Chemistry, 2004, 47(6), 1303–1314.

Rushton, D. N.
Functional Electrical Stimulation and rehabilitation—an hypothesis. Medical Engineering & Physics, 2003, 25, 75–78.

Oprea, T. I.
Virtual screening in lead discovery: A viewpoint. Molecules, 2002, 7(1), 51–62.

Poroikov, V. V., Filimonov, D. A.
How to acquire new biological activities in old compounds by computer prediction. Journal of Computer-Aided Molecular Design, 2002, 16(11), 819–824.


11 compounds


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